Expression of the class II tumor suppressor geneRIG1is directly regulated by p53 tumor suppressor in cancer cell lines
نویسندگان
چکیده
منابع مشابه
The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53.
KAI1 is a tumor metastasis suppressor gene that is capable of inhibiting the metastatic process in animals. The expression of the KAI1 gene also is found to be down-regulated during the tumor progression of prostate, breast, lung, bladder, and pancreatic cancers in humans, and this down-regulation appears to be at or posttranscription level. We have found that the tumor suppressor gene p53 can ...
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To determine whether there is any abnormalities of the p53 gene in chicken lymphoblastoid tumor cell lines derived from Marek's disease (MD), lymphoid leukosis, reticuloendotheliosis, and field tumors, some portions of p53 cDNA corresponding to core and C-terminal domains (nucleotide positions 277-1104 in the p53 open reading frame (ORF)) were sequenced. Several mutations were identified in bot...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2012
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2012.03.020